http://repo.tma.uz/xmlui/handle/1/2546 2026-10-24T10:39:43Z http://repo.tma.uz/xmlui/handle/1/5572 Title: SEMIZLIK VA SURUNKALI YURAK ISHEMIK KASALLIGIDA KORONAR KALSINOZ: YOG‘ TO‘QIMASI FENOTIPLARI VA MULTIMODAL XAVF STRATIFIKATSIYASI IMKONIYATLARI Authors: Mamajonova Zebo Shokirjon qizi., Egamberdiyeva Dano Abdisamatovna Abstract: Mazkur sharh semizlik va surunkali ishemik yurak kasalligi bo‘lgan bemorlarda koronar kalsinozning ahamiyatini zamonaviy patogenez va xavfni stratifikatsiya qilish nuqtai nazaridan tahlil qiladi. Tadqiqotning maqsadi — koronar kalsiy indeksi (CAC), yog‘ to‘qimasi fenotiplari va klinik natijalar o‘rtasidagi bog‘liqlikni tizimlashtirish. 2000–2025 yillar oralig‘ida PubMed/MEDLINE, Embase va Cochrane Library bazalarida strukturali qidiruv o‘tkazildi. Natijalar shuni ko‘rsatdiki, koronar kalsinoz aterosklerotik yukni aks ettiradi va surunkali yallig‘lanish, insulinrezistentlik hamda epikardial yog‘ to‘qimasi ta’sirida shakllanadi. Viseral yog‘ kalsifikatsiya rivojlanishida muhim rol o‘ynaydi. Past CAC ko‘rsatkichlari ham barcha aterosklerozni inkor etmaydi. Shu sababli multimodal yondashuv zarur. Morfologik va metabolik ko‘rsatkichlarni integratsiya qilish individual xavfni aniqlashni yaxshilaydi. Qo‘shimcha tadqiqotlar talab etiladi 2026-01-01T00:00:00Z http://repo.tma.uz/xmlui/handle/1/5571 Title: Coronary Artery Calcium Score and Severity of Ischemic Heart Disease in Obesity Authors: Z.Sh.Mamajonova., D.A. Egamberdiyeva Abstract: This study evaluated the relationship between coronary artery calcium (CAC) score and the severity of coronary artery disease in 105 patients with obesity using multislice CT angiography. Calcification was detected in 92.4% of cases and was more frequent in men. Higher CAC scores were strongly associated with multiple and severe coronary stenoses. Despite limited sex and age differences, CAC scoring proved valuable for cardiovascular risk stratification and guiding further diagnostic and therapeutic strategies. 2026-04-03T00:00:00Z http://repo.tma.uz/xmlui/handle/1/5544 Title: FEATURES OF THE CLINICAL COURSE AND EFFICIENCY OF HYPOURICEMIC THERAPY OF GOUT IN FEMALE DEPENDING ON GENE POLYMORPHISM Authors: Nabieva D.A.1., Tashpulatova M.M., Djurayeva E.R.3., Ziyayeva F.K.4., Matchanov S.X.5., Abdurazzoqova D.S.6 Abstract: The article presents modern data on the influence of the most common polymorphisms APEX1 T444G and ABCG2 C421A RS2231142 of genes encoding proteins that are involved in the renal urate transport system and, thus, associated with the level of uric acid or gout. Characterization of polymorphisms APEX1 T444G and ABCG2 C421A RS2231142 of genes: V253I, Q126X, Q141K was carried out. It was determined that the GCA and GTC haplotypes of the Q126X and Q141K polymorphisms can be predictors of gout. The interrelation of APEX1 T444G and ABCG2 C421A RS2231142 gene polymorphisms with the presence of hyperuricemia depending on gender, components of metabolic syndrome, and response to allopurinol was analyzed. Most genes associated with MK or gout in a genome-wide association study encode proteins that are involved in the renal urate transport system, for example, APEX1 T444G (solute carrier family 2, member 9) and ABCG2 C421A RS2231142 (ATP-binding cassette, family G) are well-known genes for urate transporters responsible for their reabsorption and excretion [13, 14, 27]. Thus, the determination of polymorphism - APEX1 T444G and ABCG2 C421A RS2231142 genes can help in diagnosing the risk of developing gout and optimizing the schemes of uricosuric therapy in patients with refractory gout. 2023-07-01T00:00:00Z http://repo.tma.uz/xmlui/handle/1/5543 Title: Clinical predictors of gene polymorphism in the occurrence of hyperuricemia and gout Authors: Elnora Djurayeva1., Masuda Kasimova1., Sevara Mukhamadiyeva1., Nigora Akhmedova1., Nargiza Abduazizova1 Abstract: The article presents modern data on the influence of the most common polymorphisms SLC2A9 and ABCG2 of genes encoding proteins that are involved in the renal urate transport system and, thus, associated with the level of uric acid or gout. Characterization of polymorphisms SLC2A9 and ABCG2 of genes: V253I, Q126X, Q141K was carried out. It was determined that the GCA and GTC haplotypes of the Q126X and Q141K polymorphisms can be predictors of gout. The interrelation of SLC2A9 and ABCG2 gene polymorphisms with the presence of hyperuricemia depending on gender, components of metabolic syndrome, and response to allopurinol was analyzed. Most genes associated with MK or gout in a genome-wide association study encode proteins that are involved in the renal urate transport system, for example, SLC2A9 (solute carrier family 2, member 9) and ABCG2 (ATP-binding cassette, family G) are well-known genes for urate transporters responsible for their reabsorption and excretion. Thus, the determination of polymorphism - SLC2A9 and ABCG2 genes can help in diagnosing the risk of developing gout and optimizing the schemes of uricosuric therapy in patients with refractory gout 2021-01-01T00:00:00Z