ENDOGENOUS PATHOLOGICAL FACTORS AS THE REASON OF SYSTEM INFLAMMATORY REACTION DURING RHEUMATOID ARTHRITIS

Abstract

Rheumatoid arthritis (RA) is an autoimmune, systemic disease that affects the joints. In RA, the body‟s immune system destroy body‟s tissue for a foreign invader. This leads immune system to attack the protective cushion of tissue and fluid between the joints. The result is swelling, stiffness, and pain in the joint. The body‟s misfiring immune system also may go after the body‟s soft tissues, like cartilage, and organs such as the heart, eyes, and veins. According to the literature, the number of publications on the study of endogenous pathological factors as the reason of systematic inflammatory reaction in patients with RA is limited. Methods: Retrospective analysis representing in this article was performed through 68 patients with RA who was received inpatient treatment in the Department of Rheumatology 3-clinic Tashkent Medical Academy (TMA) in period from 2013 to 2015. The activity of rheumatoid arthritis was estimated on DAS-28 indicators, the erythrocyte sedimentation rate (ESR) levels and quantity of leukocytes. The research included 16 patients suffering from RA without anemia (Hb>120g/l) – the first group of patients, 20 patients (second group) of RA with anemia (Hb<110g/l) and without helicobacter pylori infection and 32 patients (the third group) of RA with an anemia a positive helicobacter pylori infection. For control group, 14 almost healthy people of both sexes were chosen. Results: Cytokine attack to endotheliocytes cause "oxygen explosion" of a cell which is also associated with the increase pool middle molecular weight (MMW) on average by 1.6 times in plasma of blood and by 1.8 times in erythrocytes in patients with RA without anemia. An increase of malondialdehyde in blood erythrocytes for 25% was noted. The hepatocellular answer is shown by production and release of proteins of a sharp phase, i.e. the increase of C-reactive protein by 1.7 times and fibrinogen by 1.4 times [PL 0.05] in RA patients without anemia. Tumor necrosis factor level in patients of the III group exceeded the initial level of healthy people by 2.9 times [PL 0.05]. The cascade of anti-inflammatory cytokine at this group of patients starts the main mechanism of development of disease where IL-6 stimulates development of proteins of inflammation's sharp phase in liver, in particular C-reactive protein and fibrinogen whose contents exceeded reference values respectively by 2.9 times and by 1.9 times [PL 0.05]. Conclusion: Several endogenous pathological factors such as TNF-α, C-reactive protein, fibrinogen, malondialdehyde were determined as the reason of system inflammatory reaction in rheumatoid arthritis.