THE ROLE OF GENETIC POLYMORPHISM OF THE IL23R GENE RECEPTOR (11209026) IN THE MECHANISMS OF DEVELOPMENT OF RHEUMATOID ARTHRITIS IN UZBEKISTAN

Abstract

The presence of a relationship between polymorphism of the IL23R gene receptor (11209026) and the risk of developing rheumatoid arthritis in Uzbekistan was studied. The polymorphism of the IL23R gene receptor (11209026) was assessed by analyzing DNA samples by standard PCR. The results of a study to study the polymorphism of the IL23R gene receptor (11209026) in the general group of patients with RA and in the subgroup 1A of patients with articular RA showed the presence of statistically significant differences in the carriage of the A allele (14.1% versus 7.8%; χ2 = 4.46; P = 0.04; OR = 1.95; 95% CI: 1.05-3.62) and (15.5% versus 7.8%; χ2 = 5.43; P = 0.02; OR = 2.176; 95% CI: 1.131-4.185), respectively, as well as a clear tendency towards an increased risk of developing RA in carriers of the G / A genotype (22.7% versus 15.6%; χ2 = 1.73; P = 0.19; OR = 1.58; 95% CI: 0.798-3.145) and (25.7% versus 15.6%; χ2 = 2.83; P = 0.09; OR = 1.87; 95% CI: 0.902-3.876), respectively. Therefore, allele A and genotype G / A can be considered as molecular genetic markers that increase the likelihood of developing articular RA.