Modified surface hemoglobin (PEG HB, PHP, HAEMOSPAN)

Abstract

Modified surface hemoglobin is produced by attaching large molecules, such as polyethylene glycol, to the surface groups of lysine. This modification increases the viscosity and oncotic pressure of the solution [4]. These solutions can moderately constrict blood vessels. Due to the small size of the hemoglobin molecules, they can pass through small vessels and saturate areas with oxygen that are inaccessible to erythrocytes. This makes it useful for treating patients with strokes, as well as increasing the sensitivity of tumor cells to radiation or chemotherapy. Additionally, the vasopressor effects can be used to treat hypotension after septic shock. This type of hemoglobin also has a low frequency of antibody production.