ASPECTS OF MODERN TREATMENT OF ATOPIC DERMATITIS

Abstract

Atopic dermatitis (AtD) is one of the most common skin diseases, affecting about 20% of children and 5% of adults in developed countries. The dis ease is multifactorial in etiology. Among the genetic factors, the main attention is paid to the mutation of the gene encod ing the synthesis of the filaggrin protein, which is involved in the functioning of the skin barrier. In the genesis of im mune disorders in AD, the role of cy tokines regulating the synthesis of IgE - interleukins (IL) -4, -5, -12, -13, -31 is studied. Chronic stress in itchy derma titis contributes to the development of anxiety and depressive disorders that reduce the quality of life, and stress-me diated increase in cortisol levels can be significant in disrupting the barrier func tion of the skin.