Iron Metabolism Regulation and Its Impact on Embryo Quality in Assisted Reproductive Technologies

Abstract

This study evaluates the influence of ferritin concentrations in serum and follicular fluid on the morphological quality of embryos produced during in vitro fertilization (IVF). A total of 65 women diagnosed with infertility, aged 25 to 39, were enrolled and divided into two subgroups based on the timing of iron supplementation. Group 2A received iron supplements concurrently with ovarian stimulation, whereas Group 2B completed iron intake two months before stimulation initiation. Ferritin measurements were taken from both blood and follicular fluid samples on the day of oocyte retrieval. The findings demonstrate that moderately elevated ferritin levels support the development of higher-quality embryos, while excessive iron levels may compromise embryonic structure and viability. The results suggest that a personalized iron management strategy is essential for optimizing IVF outcomes