EVALUATION OF MODERN DIAGNOSTIC METHODS FOR CHROMOSOMAL DISORDERS IN EARLY PREGNANCY

Abstract

According to the World Health Organization (WHO), 1 in every 700-100 children born has a genetic disorder, such as chromosomal abnormalities, including Down syndrome. Birth defects include structural abnormalities and genetic abnormalities in the fetus. Chromosome G-band karyotyping analysis is widely used as a method for detecting genetic abnormalities in clinical prenatal diagnosis. However, this approach has several limitations, including the necessity of performing cell culture, a lengthy detection wait period (2 to 3 weeks), and a low resolution (only chromosomal abnormalities > 5–10 Mb can be detected using this approach)