ЎЗБЕК ПОПУЛЯЦИЯСИДА СУРУНКАЛИ ГЛОМЕРУЛОНЕФРИТ РИВОЖЛАНИШИДА TNF-α ГЕНИ G-308A ПОЛИМОРФИЗМИНИНГ ТАРҚАЛИШ ДАРАЖАСИНИ ЎРГАНИШ

Abstract

Objective: To study the genotypes of the TNF-α gene (G-308A) in mixed and nephrotic forms of chronic glomerulonephritis and to an alyze their distribution. Material and methods: The study was con ducted at the nephrology department of the multidisciplinary clinic of the Tashkent Medical Academy. The study involved 80 patients aged 18 to 60 years diagnosed with chronic glomerulonephritis. The control group consisted of 125 people. All subjects were born in Uzbekistan and are not related. Results: The G allele and the GG, GA genotypes of the G-308A polymorphism of the TNF-α gene are significantly associated with the development of the disease, but do not reach reliable signifi cance. In the future, individual therapy and the use of biomarkers that determine the prognosis of the disease are proposed based on these genetic markers. Conclusions: The study of polymorphisms of other inflammatory and immune genes will allow a deeper understanding of the pathogenesis of chronic glomerulonephritis.