Cytokine Status in Pregnant Women Vaccinated Against COVID-19

Abstract

Background. One of the main measures for the specific prevention of corona virus infection (COVID-19) is to vaccinate the population, including pregnant women at risk, against this disease. Studies investigating the effects of the COVID-19 vaccine on obstetric and perinatal outcomes have been based on data that show no evidence that vaccines pose a risk to pregnant women or the fetus, or that vaccines have adverse effects on pregnancy or perinatal outcomes. The purpose of the study was to study the features of cytokine status in pregnant women vaccinated against COVID-19. Methods. 120 pregnant women from 16 to 36 weeks of gestation, vaccinated against COVID-19 in the second and third trimesters, were examined. Immunological studies were carried out to determine the content of cytokines IL-1β, IL-4, IL-6, IL-8, IL-10 and IFNγ in blood serum. Results. In pregnant women included in the study, regardless of which trimester and with which component of pregnancy the vaccine against SOVID-19 was vaccinated, the examination of the amount of cytokines 1 week after vaccination showed a 1.1-fold increase in the amount of IL-1, IL-6 and IFNγ cytokines compared to women in the comparison group. A 1.2-fold decrease in IL-4 and IL-8 was observed, but these changes did not exceed the normal range, and in the examination 2 and 3 weeks after vaccination, the quantitative indicators of all the above-mentioned cytokines were determined at the normal level. Conclusion. Study of cytokine status in pregnant women vaccinated against COVID-19, regardless of which component of the vaccine was administered in which trimester of pregnancy, 1 week after vaccination, IL-1, IL-6 and IFNγ cytokines were 1.1 times compared to the comparison group. increased, and IL-4 and IL-8 cytokines decreased by 1.2 times, and in the examination 3 weeks after vaccination, it was found that the quantitative indicators of all cytokines were at the normal level, which indicates that the vaccine against COVID-19 has a negative effect on the state of cytokines indicates that he did not reveal the secret.