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http://repo.tma.uz/xmlui/handle/1/1946Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Avezova G.S. | - |
| dc.date.accessioned | 2025-08-24T11:48:03Z | - |
| dc.date.available | 2025-08-24T11:48:03Z | - |
| dc.date.issued | 2025 | - |
| dc.identifier.uri | http://repo.tma.uz/xmlui/handle/1/1946 | - |
| dc.description.abstract | Maqsad: IL17A (G-197A) genining polimorfizm holat lari bolalarda gemorragik vaskulit (GV) rivojlanishi va un ing klinik shakllari bilan bog‘liqligini aniqlash maqsadida o‘rganildi. Material va usullar: tadqiqot doirasida 2022 2024 yillarda 183 nafar bola ishtirokida molekulyar-genetik tahlillar olib borildi. Tadqiqot ishtirokchilari ikki guruhga ajratildi: GV bilan kasallangan 93 nafar bola va nazorat si fatida 90 nafar sog‘lom bola. Genotiplash PZR va restriksiya tahlili asosida amalga oshirildi. Natijalar: GV bilan kasal langan bolalarda, ayniqsa aralash (og‘ir) shaklida, IL17A G-197A genining A alleli va AA genotipi sezilarli darajada ko‘p uchradi. AA genotipi og‘ir shakllarda 8 barobar, GA esa 3,5 barobar ko‘p kuzatildi (p<0.01). Nazorat guruhida esa G allelining yuqori chastotasi aniqlanib, bu uning protektiv ahamiyatga ega ekanini ko‘rsatdi. Xulosa: IL17A (G-197A) gen polimorfizmi bolalarda GV rivojlanishi va og‘ir kechиши uchun muhim genetik marker sifatida tavsiflanmoqda. Ushbu marker klinik prognoz va erta tashxisda samarali qo‘llanilishi mumkin. | en_US |
| dc.language.iso | other | en_US |
| dc.publisher | O'zbekiston, Toshkent | en_US |
| dc.relation.ispartofseries | UO’K:;616.13.14-002.15-053.2: 2:612.017.1:575 -071-036 | - |
| dc.subject | IL17A, gen polimorfizmi, gemorragik va skulit, sitokin, bolalar, og‘ir kechish, molekulyar-genetik tahlil | en_US |
| dc.title | IL17АGENI POLIMORFIZMI VA GEMORRAGIK VASKULIT: BOLALARDA GENETIK XAVF OMILLARINING MOLEKULYAR TAHLILI | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | Articles | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Авезова вестник 8 25. в печать+.pdf | IL17АGENI POLIMORFIZMI VA GEMORRAGIK VASKULIT: BOLALARDA GENETIK XAVF OMILLARINING MOLEKULYAR TAHLILI | 1.59 MB | Adobe PDF | View/Open |
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