Significance of Endothelial Dysfunction in the Development of HCV Etiology Chronic Hepatitis and Liver Cirrhosis

Abstract

The disruption of intragepatic hemodynamics is a key factor in the pathogenesis and progression of liver diseases, particularly liver cirrhosis and chronic hepatitis. This hemodynamic alteration leads to endothelial dysfunction, a condition that triggers the release of biologically active substances impacting the balance between pro-coagulant and anticoagulant factors. Such an imbalance contributes to a pro-thrombotic state in the liver, which exacerbates intrahepatic fibrosis, cellular apoptosis, and other degenerative changes, accelerating disease progression. This abstract explores the significance of endothelial dysfunction as both a cause and consequence in chronic liver disease, highlighting its role as a potential target for therapeutic intervention aimed at preventing or slowing the advance of cirrhosis. Addressing endothelial damage may thus offer new avenues for treatment strategies, improving outcomes for patients with chronic liver disease.