THE INFLUENCE OF THREE-COMPONENT SECOND-LINE REGIMENS ON THE STATE OF OXIDATIVE STRESS AND ANAEROBIC GLYCOLYSIS IN THE GASTRIC MUCOSA DURING THE TREATMENT OF ULCER DEASEASE

Abstract

Objective: To study the state of oxidative stress and anaerobic glycolysis in the gastric mucosa during treat ment of experimental ulcers with three-component sec ond-line therapy regimens. Material and methods: The experiments were conducted on 30 male white rats of a mixed population weighing 150-190 g. The experimental ulcer model was induced by the method of V.A. Vertelkin as modified by I.A. The animals were divided into 5 groups of 6 individuals each: Intact group (control); animals with experimental ulcers; ulcer without treatment; ul cer + esomeprazole + amoxicillin + tetracycline; ulcer + esomeprazole + amoxicillin + furazolidone. Results: Bio chemical analysis showed that the furazolidone regimen significantly increased the concentration of L-lactate and malondialdehyde, indicating increased activity of anaer obic glycolysis and increased lipid peroxidation. These changes indicate worsening microcirculatory disorders and increased oxidative stress in the gastric mucosa. The combination of esomeprazole, amoxicillin and tetracy cline resulted in a significant decrease in both MDA and L-lactate levels, indicating a pronounced antioxidant ef fect and normalization of glycolytic metabolism. Conclu sions: The obtained data confirm the therapeutic benefit of triple therapy with tetracycline for the correction of metabolic disorders in the gastric mucosa and improving the results of peptic ulcer treatment.