Сурункали юрак етишмовчилигида буйрак дисфункциясини эрта ташхислашда эндотелиал гликокаликс ва унинг маркерларининг аҳамияти

Abstract

Chronic heart failure (CHF) is a complex clinical syndrome with high morbidity and mortality, which in most cases is accompanied by kidney damage and leads to the development of cardiorenal syndrome. As a result of scientific research in recent years, it has been established that endothelial glycocalyx (EG) dysfunction plays a significant role in the deterioration of renal function in this disease. High levels of EG markers, such as syndecan-1, heparan sulfate and hyaluronic acid in the blood serum, are closely associated with microalbuminuria, systolic dysfunction and glomerular filtration rate. Since traditional biomarkers of renal dysfunction - creatinine and cystatin-C - change at some late stages of the disease, identifying factors specific to EG dysfunction, along with them, will allow early detection of a decrease in renal reserve and the development of interstitial fibrosis, choosing adequate treatment options and improving the outcomes of the underlying disease.