MORPHOLOGICAL CHANGES IN THE BLOOD VESSELS OF THE PLACENTA’S TISSUE OF PREGNANT WOMEN WITH ECLAMPSIA

Abstract

The pathogenesis of eclampsia can be conceptually described as a cascade beginning with impaired immunological adaptation, compounded by underlying genetic predispositions. These disturbances hinder normal trophoblast invasion and prevent the physiological remodeling of the muscular layer of the spiral arteries. As a consequence, regulatory mechanisms governing vasoconstrictors and vasodilators become disrupted, giving rise to generalized vasospasm and profound alterations in systemic and organ-specific hemodynamics, including the utero–placental–fetal circulation. This sequence culminates in widespread endothelial injury.