Morphological Changes of Internal Organs in Experimental Interstitial Lung Lesions

Abstract

This study presents the results of a pathomorphological investigation of internal organs in rats with experimen tally induced interstitial pneumonia caused by chronic tobacco smoke exposure. Pronounced inflammatory-de structive changes were revealed in the lung tissue, including peribronchial sclerosis, lymphoid infiltration, and emphysematous alterations. In addition to pulmonary pathology, dystrophic changes were observed in the liver, kidneys, heart, and brain, indicating systemic inflammatory response and multiple organ dysfunction. These find ings highlight the pathogenetic role of chronic inflammation and provide a basis for further studies and therapeu tic assessment.