CARBOHYDRATE METABOLISM PARAMETERS IN PATIENTS WITH MASLD DEPENDING ON THE PRESENCE OF RENAL DYSFUNCTION

Abstract

Objective: To investigate carbohydrate metabolism parameters in patients with metabolic dysfunction–associated fatty liver disease (MAFLD) depending on the presence of renal dysfunction. The study assessed kidney functional status in young patients with metabolic dysfunction–associated fatty liver disease (MAFLD). A total of 105 patients aged 18–45 years with ultrasound-confirmed hepatic steatosis were included and divided into two groups: MAFLD (n = 81) and MAFLD + chronic kidney disease (CKD) (n = 24). Patients with MAFLD and renal dysfunction demonstrated significantly higher levels of fasting glucose, insulin, HbA1c, and metabolic indices—HOMA-IR, TyG, and METS-IR—compared with MAFLD patients without renal impairment. The integral indices of insulin resistance showed significant correlations with eGFR and albuminuria: HOMA-IR, TyG, and METS-IR were inversely associated with eGFR and positively associated with the albumin-to-creatinine ratio (A/Cr). Young patients with concomitant MAFLD and CKD exhibit a marked exacerbation of metabolic disturbances, including increases in HOMA-IR, TyG, and METS-IR, indicating more pronounced insulin resistance. Integral insulin resistance indices—HOMA-IR, TyG, and METS-IR—demonstrate significant correlations with eGFR and albuminuria.