PHOSPHATE DISORDERS AND TUBULAR DYSFUNCTION AS CLINICAL MANIFESTATION OF RICKETS-LIKE DISEASE IN DIABETES IN CHILDREN: CLINICAL ASPECTS AND MOLECULAR MECHANISMS

Abstract

Rickets-like diseases are rare hereditary disorders affecting phosphatecalcium metabolism and bone mineralization, often challenging to diagnose due to overlapping symptoms and genetic diversity. Advances in molecular genetics enable precise diagnosis and personalized treatment, yet data on their prevalence and genetic features in Uzbekistan are limited. Understanding the molecular basis of rickets-like diseases in the Uzbek population will contribute to improved diagnostic algorithms and therapeutic strategies for affected children.