INFLUENCE OF PSYCHOLOGICAL AND PERSONALITY CHARACTERISTICS OF PATIENTS WITH CORONARY ARTERY DISEASE ON THE PHENOTYPE OF PLATELETS

Abstract

To assess the influence of psychological distress on the morphological characteristic of the blood platelets depending on the level of anxiety-depressive syndrome in patients with cardiac pathology, examined 112 persons, of whom 84 patients with coronary artery disease, angina pectoris FC II-III, whose age average was 60.9±1.46 years. Assessment of the level of psychoemotional status was conducted using hospital scale of anxiety and depression - HADS. To determine the personality type D was used a questionnaire - DS14. Study of the phenotype of platelets was performed using flow cytometry. The patients were divided into 2 groups: I group (n=40) patients with anxiety-depressive syndrome and the II group (n=44) without anxiety and depression. When assessing the interrelated effects of anxiety-depressive syndrome and psychological distress at the performance of platelet profile in patients, the differences in the groups according to the platelet phenotype. The patients of the I group the average platelet (PLT) made up 312,1±17,17х109/L, while in patients with type D value to PLT averaged 316,7±17,54х109/L, which was dominated by above average PLT-220,4±10,48 х109/L in the II group (p<0,001). The average value of the width of the platelets distribution (PDW) was significantly higher in I group patients at a mean of 17.0±0,94 fL vs 13,6±0,76 fL compared with patients of II group (p<0,05). The average platelet volume (MPV) of the I group on the background of anxiety and depression were statistically significantly prevailed the value MPV, which amounted to an average of 11.3±0,42, in contrast to performance II and control group of 9.7±0,23 and 8.7±0,28 fL, respectively (p<0,001). Increased functional activity of platelets in patients with ischemic heart disease, due to the influence of anxiety and depression associated with personality.