| DC Field | Value | Language |
|---|
| dc.contributor.author | Abdigaffar G. Gadayev., Matluba E. Rakhimova., Yulduz B. Bakhronova | - |
| dc.date.accessioned | 2026-10-17T15:16:11Z | - |
| dc.date.available | 2026-10-17T15:16:11Z | - |
| dc.date.issued | 2026 | - |
| dc.identifier.uri | http://repo.tma.uz/xmlui/handle/1/5503 | - |
| dc.description.abstract | Background. Renal dysfunction substantially worsens the prognosis of patients with heart failure (HF). Endothelial glycocalyx degradation has recently emerged as a key mechanism underlying cardiorenal syndrome, while syndecan-1 has gained attention as a circulating biomarker of endothelial injury. However, its relationship with renal dysfunction and cardiac hemodynamics in HF remains insufficiently characterized.
Objective. To evaluate the association between serum syndecan-1 concentrations and cystatin C-based renal function, cardiac hemodynamic parameters, inflammatory biomarkers, and to determine its diagnostic value for the early detection of renal dysfunction in patients with chronic heart failure (CHF). | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | O'zbekiston, Toshkent (Central Asian Journal of Medicine) № 7 | en_US |
| dc.relation.ispartofseries | UDC;616.379-008.64:616-092.18 | - |
| dc.subject | chronic heart failure; cardiorenal syndrome; syndecan-1; endothelial glycocalyx; cystatin C; renal dysfunction; NT-proBNP; biomarkers. | en_US |
| dc.title | DIAGNOSTIC VALUE OF SYNDECAN-1 FOR EARLY DETECTION OF RENAL DYSFUNCTION AND ITS ASSOCIATION WITH CARDIAC HEMODYNAMIC AND BIOCHEMICAL PARAMETERS IN HEART FAILURE | en_US |
| dc.type | Article | en_US |
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