DISTURBANCE IN THE COMPOSITION OF THE INTESTINAL MICROFLORA IN THE MECHANISMS OF THE FORMATION OF CLINICAL MANIFESTATIONS IN PATIENTS WITH CHRONIC PANCREATITIS

Abstract

Objective: To study the role of intestinal microflora disorders in the formation of clinical manifestations of chronic pancreatitis and evaluate the effectiveness of therapy aimed at restoring intestinal microbiocenosis. Material and methods: A prospective analysis of the treatment results of 50 patients for the period 2021-2023 was carried out. There were 27 men (54%), 23 women (46%). There were 4 (10.4%) women under 44, 8 (40.3%), 45-59, 11 (49.3%) over 60, 3 (8.6%), 12 (44) men respectively. .4%) and 7 (26%). Results: Among patients with bacterial overgrowth in the small intestine, pain due to intestinal dysfunction was observed in 80.3%, duodenal hypertension - in 71.8%, watery diarrhea was observed in 67.6%, flatulence - in 84.5%, bitterness in the mouth – in 69%, nausea – in 57.7%. Conclusions: Intestinal and colon dysbiosis, as well as the severity of dysbiotic disorders in the colon, directly depended on the severity of exocrine pancreatic insufficiency