Cognitive Disorders in Post-Traumatic Encephalopathies and Increase the Effectiveness of Treatment

Abstract

Post-traumatic encephalopathy (PTE) is a chronic progressive condition that develops after traumatic brain injury and is characterized by cognitive, morphological, and functional impairments of the central nervous system. The present study aimed to evaluate cognitive disorders in patients with PTE and assess the effectiveness of комплекс therapy. A total of 100 patients were examined using clinical, neuropsychological (MMSE), neuroimaging (MRI), and functional (EEG) methods before and after treatment. Prior to therapy, most patients demonstrated pre-dementia cognitive impairment (MMSE 24–25 points), along with diffuse cerebral atrophy, gliosis, leukoaraiosis, and pathological EEG changes. After комплекс treatment, MMSE scores improved to 26–27 points, accompanied by stabilization of MRI findings and normalization of EEG parameters. The results confirm the interrelationship between structural, functional, and cognitive disturbances in PTE and demonstrate the clinical effectiveness of timely comprehensive therapeutic intervention.