METABOLIC SYNDROME AND COGNITIVE DISORDERS

Abstract

Metabolic syndrome (MetS), a cluster of diseases that includes central obesity, hypertension, hyperglycemia, and dyslipidemia, has emerged as a significant public health problem. In addition to its association with cardiovascular disease and diabetes, MetS is increasingly associated with cognitive impairment and neurodegenerative diseases such as Alzheimer's disease. The underlying mechanisms linking MetS to cognitive decline include chronic inflammation, insulin resistance, oxidative stress, and vascular dysfunction, which impair brain health and neuronal function. This article explores the complex relationship between MetS and cognitive impairment, highlights the physiological and biochemical pathways, and discusses preventive and therapeutic strategies to mitigate the impact of MetS on cognitive health. Recognizing the interrelationship between metabolic health and cognitive function is critical for developing integrated approaches to address the dual burden of physical and neurological diseases.