POLYARTHRITIC AND SYSTEMIC JUVENILE IDIOPATIC ARTHRITIS WITH COMBINATION OF TYPE DIABETES MELLITUS

Abstract

Background and Goals. Low serum levels of osteocalcin (OC), hemoglobin, and osteoporosis are linked to polyarthritic and systemic juvenile idiopathic arthritis (PJIA, SJIA), as well as type 1 diabetes mellitus (T1DM) and polyarthritic and systemic juvenile idiopathic arthritis (PJIA, SJIA). We looked into the relationship between serum OC levels and JIA, as well as how T1DM affected this relationship in participants. Our objective is to learn more about the underlying illness characteristics of chronic rheumatic diseases, which are most frequently seen in children, and to update existing knowledge and propose new therapeutic approaches. Methods: This study compares osteocalcin (OC) concentrations between participants with PJIA, SJIA, and type 1 diabetes (T1DM) (n = 20) and age, gender, and body mass index (BMI)-matched participants without T1DM (n = 40) in patients with OJIA (oligoarthritic the juvenile idiopathic arthritis), and it investigates relationships between OC concentrations JIA and T1DM. IMMULITE 2000 analyzers were used to quantify the amount of OC in blood plasma that had been treated with heparin. This in vitro investigation was conducted to track mineral metabolism and identify osteoporosis. Only an unfragmented OC molecule, not one that has been broken up, may be detected using the IMMULITE OC test. Results: Participants who had T1DM and both PJIA and SJIA had very low OC concentrations. Concentrations of OC were essentially average for OJIA individuals without T1DM. Conclusions: Lower OC concentrations in patients with PJIA and SJIA were associated with T1DM.In JIA patients who also had T1DM, OC was sufficient to detect and prevent osteoporosis. Patients with OJIA who did not have T1DM had serum levels of OC that were in the general area of the normal range. Participants' serum OC levels and OJIA levels were not correlated.