Abstract:
It is known that in liver cirrhosis, the progression of fibrotic changes, disruption of tissue
architecture, and the formation of regenerative nodules lead to progressive necrotic inflammation. As a
result, the intrahepatic veins, portal vein branches become narrowed, and portal hypertension develops. In
recent years, research has increasingly focused on the importance of cytokines in the pathogenesis of liver
cirrhosis and the development of disease manifestations. In physiological conditions, cytokines regulate
the function of hepatic stellate cells, which play a key role in fibrogenesis. Hepatic stellate cells not only
produce profibrotic factors but also counterbalance this process by producing antifibrotic factors.
