THE ROLE OF ASYMMETRIC DIMETHYLARGININE AS A PREDICTOR OF CARDIOVASCULAR DISEASES

Abstract

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), an enzyme responsible for producing nitric oxide (NO), a molecule with various cardiovascular protective effects including vasodilation and inhibition of platelet aggregation. Elevated levels of ADMA have been associated with endothelial dysfunction, inflammation, and oxidative stress, all of which are key factors in the development and progression of cardiovascular diseases (CVD).