Abstract:
The disruption of intragepatic hemodynamics is a key factor in the pathogenesis and progression of liver
diseases, particularly liver cirrhosis and chronic hepatitis. This hemodynamic alteration leads to endothelial dysfunction, a
condition that triggers the release of biologically active substances impacting the balance between pro-coagulant and
anticoagulant factors. Such an imbalance contributes to a pro-thrombotic state in the liver, which exacerbates intrahepatic
fibrosis, cellular apoptosis, and other degenerative changes, accelerating disease progression. This abstract explores the
significance of endothelial dysfunction as both a cause and consequence in chronic liver disease, highlighting its role as a
potential target for therapeutic intervention aimed at preventing or slowing the advance of cirrhosis. Addressing endothelial
damage may thus offer new avenues for treatment strategies, improving outcomes for patients with chronic liver disease.
