Abstract:
Objective: to investigate the relationship between indexes of dyslipidemia and immunological
changes in patients with tophaceous gout and asymptomatic hyperuricemia.
Patients and methods. The study included 85 male patients: 1st group – 49 patients with
primary chronic gout according to Wallace S.L. criteria, 2nd (control) group – 36 patients with
asymptomatic hyperuricemia. The levels of uric acid (UA), C-reactive protein (CRP), fasting glycemia,
lipid profile – total cholesterol (TC), triglycerides (TG), high-density (HDL), low density (LDL), very
low density (VLDL) lipoproteins, atherogenic ratio (AR); cytokine concentrations: interleukin-1β (IL
1β), tumor necrosis factor-α (TNF-α), IL-4, IL-6, IL-8, IL-10 and IL-18 in the blood serum using
enzyme-linked immunosorbent assay.
