Abstract:
Metabolic syndrome (MetS), a cluster of diseases that includes
central obesity, hypertension, hyperglycemia, and dyslipidemia,
has emerged as a significant public health problem. In addition
to its association with cardiovascular disease and diabetes, MetS
is increasingly associated with cognitive impairment and
neurodegenerative diseases such as Alzheimer's disease. The
underlying mechanisms linking MetS to cognitive decline include
chronic inflammation, insulin resistance, oxidative stress, and
vascular dysfunction, which impair brain health and neuronal
function. This article explores the complex relationship between
MetS and cognitive impairment, highlights the physiological and
biochemical pathways, and discusses preventive and therapeutic
strategies to mitigate the impact of MetS on cognitive health.
Recognizing the interrelationship between metabolic health and
cognitive function is critical for developing integrated
approaches to address the dual burden of physical and
neurological diseases.
