THE SIGNIFICANCE OF CYTOKINES IN LIVER DISEASES

Abstract

It is known that in liver cirrhosis, the progression of fibrotic changes, disruption of tissue architecture, and the formation of regenerative nodules lead to progressive necrotic inflammation. As a result, the intrahepatic veins, portal vein branches become narrowed, and portal hypertension develops. In recent years, research has increasingly focused on the importance of cytokines in the pathogenesis of liver cirrhosis and the development of disease manifestations. In physiological conditions, cytokines regulate the function of hepatic stellate cells, which play a key role in fibrogenesis. Hepatic stellate cells not only produce profibrotic factors but also counterbalance this process by producing antifibrotic factors.