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Please use this identifier to cite or link to this item: http://repo.tma.uz/xmlui/handle/1/2331
Title: ROLE OF SYSTEMIC INFLAMMATORY BIOMARKERS IN DETERMINING DISEASE ACTIVITY AND CLINICAL PROGRESSION OF RHEUMATOID ARTHRITIS
Authors: Shakhnoza Kh. Mirzayeva - independent researcher Aida A. Eshmurzaeva - D.M.Sc, professor Khamid M. Marufkhanov - D.M.Sc. Tashkent State Medical University, Tashkent, Uzbekistan sh.mirzayeva5358@gmail.com
Keywords: Rheumatoid Arthritis (RA), Inflammatory Biomarkers, TLR2 (Toll-Like Receptor 2), Cytokines (IL-1, IL-6, TNF-α), Extra-Articular RA, Articular RA, Disease Activity Score (DAS28).
Issue Date: 10-Apr-2025
Abstract: Growing evidence suggests that systemic inflammatory mediators play a decisive role in rheumatoid arthritis progression. Within this research, the levels and diagnostic value of key biomarkers were assessed among patients with different clinical forms of RA. The extra-articular variant displayed a more aggressive inflammatory profile, accompanied by significantly raised IL-1, IL-6, and TNF-α. Furthermore, increased TLR2 activity was identified as a critical factor in disease mechanisms.
URI: http://repo.tma.uz/xmlui/handle/1/2331
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