Decline in Renal Function and Systemic Inflammation in COPD: Clinical Significance of IL-6

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic disorder characterized by persistent and progressive bronchial obstruction and is not limited to local respiratory abnormalities, but is also accompanied by systemic effects and various comorbid conditions. In addition to local bronchopulmonary inflammation, systemic inflammation, oxidative stress, endothelial dysfunction, hypoxemia, and microcirculatory disturbances play an important role in the pathogenesis of the disease. These mechanisms may contribute to the development of various comorbid conditions in COPD, including impairment of renal functional status.