DIAGNOSTIC VALUE OF SYNDECAN-1 FOR EARLY DETECTION OF RENAL DYSFUNCTION AND ITS ASSOCIATION WITH CARDIAC HEMODYNAMIC AND BIOCHEMICAL PARAMETERS IN HEART FAILURE

Abstract

Background. Renal dysfunction substantially worsens the prognosis of patients with heart failure (HF). Endothelial glycocalyx degradation has recently emerged as a key mechanism underlying cardiorenal syndrome, while syndecan-1 has gained attention as a circulating biomarker of endothelial injury. However, its relationship with renal dysfunction and cardiac hemodynamics in HF remains insufficiently characterized. Objective. To evaluate the association between serum syndecan-1 concentrations and cystatin C-based renal function, cardiac hemodynamic parameters, inflammatory biomarkers, and to determine its diagnostic value for the early detection of renal dysfunction in patients with chronic heart failure (CHF).