Abstract:
Modified surface hemoglobin is produced by attaching large molecules, such as
polyethylene glycol, to the surface groups of lysine. This modification increases the
viscosity and oncotic pressure of the solution [4]. These solutions can moderately
constrict blood vessels. Due to the small size of the hemoglobin molecules, they can pass
through small vessels and saturate areas with oxygen that are inaccessible to
erythrocytes. This makes it useful for treating patients with strokes, as well as
increasing the sensitivity of tumor cells to radiation or chemotherapy. Additionally, the
vasopressor effects can be used to treat hypotension after septic shock. This type of
hemoglobin also has a low frequency of antibody production.
