Abstract:
It has been established that small-sized circulating immune complexes have
great pathological potential, while a high level of small circulating immune complexes
shows an active fight of immunity against virus antigens, on the one hand, and on the
other hand, is associated with a violation of the mechanisms of virus elimination, which
plays a significant role in the formation and maintaining the malignant process. All this
contributes to the violation of immune regulation, triggering the mechanisms of
carcinogenesis with the development of the disease. Thus, the combined determination
of the level of VEGF, the CD95+ apoptosis marker, and the IRI immunoregulation index
in complex clinical cases improves the diagnosis of OPR and allows timely prediction of
a more severe course of oropharyngeal cancer to avoid unnecessary biopsies or
sectoral resections.
