Abstract:
Atopic dermatitis (AtD) is
one of the most common skin diseases,
affecting about 20% of children and 5%
of adults in developed countries. The dis
ease is multifactorial in etiology. Among
the genetic factors, the main attention is
paid to the mutation of the gene encod
ing the synthesis of the filaggrin protein,
which is involved in the functioning of
the skin barrier. In the genesis of im
mune disorders in AD, the role of cy
tokines regulating the synthesis of IgE - interleukins (IL) -4, -5, -12, -13, -31 is
studied. Chronic stress in itchy derma
titis contributes to the development of
anxiety and depressive disorders that
reduce the quality of life, and stress-me
diated increase in cortisol levels can be
significant in disrupting the barrier func
tion of the skin.
