Abstract:
Objective: To determine the structural and functional
features of postnatal development of the thyroid gland in
the offspring under conditions of intrauterine exposure
to pyrethroid pesticides. Material and methods: The
experiments were conducted on white sexually mature non
pregnant female Wistar rats weighing 150-180 g, as well as on
their offspring. Animals of the experimental groups received
the pesticide fipronil (Vigor) at a dose of 3.6 mg/kg and the
insecticide fastokin at a dose of 8 mg/kg daily until the end of
the experiments. The material for the study, including thyroid
gland samples, as well as blood serum of mothers and their
offspring, were collected from the offspring of all groups of
animals on the 3rd, 7th, 14th, 21st, and 30th days after birth.
Results: Prenatal exposure to pyrethroid pesticides can alter
the normal processes of postnatal ontogenesis of the thyroid
gland in the offspring. The main structural and functional
mechanisms of the negative impact of pyrethroids on the
development of the thyroid gland during pregnancy have been
identified. Conclusions: In the mechanism of development of
thyroid dysfunction in offspring, an imbalance between the
processes of proliferation and apoptosis of thyrocytes has
been revealed, which leads to a weakening of the formation
of thyroid follicles, as well as to submicroscopic changes
indicating a violation of the secretory activity of thyrocytes.
