CHANGES OF CYTOKINE PROFILE THE DURING REHABILITATION PERIOD AFTER SURGICAL TREATMENT OF PELVIC ORGAN PROLAPSE

Abstract

Objective: To determine the level of proinflam mato- ry and anti-inflammatory cytokines in the blood serum of patients who underwent anterior colporrhaphy and posterior colpoperineoplasty levatorplasty. Material and methods: 90 patients with different stages of pelvic or gan prolapse according to the POP-Q classification were observed, who were divided into two groups depending on the use of PRP therapy. Results: During the first week after surgery, proinflammatory and anti-inflammatory cytokines were administered to patients in both groups. After 30 days of the postoperative period, the level of an ti-inflammatory cytokines was higher in the group where PRP therapy was performed. Surgical trauma can cause acute systemic inflammation, which initially plays a role in immune defense against bacterial infection and in the wound healing process. Conclusions: When using PRP therapy, wound healing can be accelerated, and it is also possible to shorten the rehabilitation period with an im provement in its course. Keywords: cytokines, inflamma tion, pelvic organ prolapse, rehabilitation period after PRP therapy.