Abstract:
Aim of the study. To study the clinical and morphological changes of fatal liver damage
in acute fatty hepatosis of the liver (AFH) in pregnant women.
Materials and methods. A 26-year-old pregnant woman with gestosis, anemia, and
duodenal ulcer was taken. At the 24th week of pregnancy, the first pre-icteric stage of AFLP
was diagnosed against the background of gradually developing gestosis. Clinically, symptoms
such as weakness, lethargy, nausea, vomiting, abdominal discomfort and pain were observed.
At the 25th week of pregnancy, the next stage of AFLP developed, characterized by severe
jaundice, nausea, repeated gastrointestinal bleeding, post-hemorrhagic anemia, and
disseminated intravascular coagulation syndrome (DIC), which ultimately led to death.
Histological sections were deparaffinized and stained with hematoxylin and eosin for
microscopic examination.
Conclusion. This study presents a clinico-morphological analysis based on autopsy of a
mother who died of acute fatty liver disease (AFLD) during pregnancy. In the pre-icteric stage,
clinical signs such as weakness, fatigue, nausea, vomiting, abdominal discomfort and pain were
associated with diffuse microvesicular fat accumulation. In the second (icteric) stage,
pathological morphological changes in the liver - diffuse fatty degeneration, necrobiota of
nuclear structures, sinusoidal congestion and focal diapedetic hemorrhages - were more
pronounced. In this stage, degenerative and necrotic processes spread to other parenchymal
organs, for example, microvesicular fatty degeneration of the renal tubular epithelium and the
subendocardial zone of the myocardium.
