Incidence and risk factors of endocrine infertility in women: retrospective analysis

Abstract

Endocrine infertility is one of the most prevalent pathological conditions among women of reproductive age, primarily caused by hyperprolactinemia, hypothyroidism, and polycystic ovary syndrome (PCOS). A retrospective analysis of medical records from 200 women (2020–2023, Tashkent) revealed that endocrine dysfunction accounted for 77% of infertility cases (hyperprolactinemia – 23%, hypothyroidism – 26%, PCOS – 28%). Key risk factors included age (OR=3.5; p<0.001), inflammatory processes (OR=2.8; p<0.01), long-term contraception (OR=2.2; p<0.05), diabetes mellitus (OR=2.6; p<0.01), hypertension (OR=2.1; p<0.05), and stress (OR=2.4; p<0.05). These findings highlight the importance of early detection of endocrine infertility and risk factor assessment to develop effective individualized therapeutic strategies.