Abstract:
Objective: To study the state of oxidative stress and
anaerobic glycolysis in the gastric mucosa during treat
ment of experimental ulcers with three-component sec
ond-line therapy regimens. Material and methods: The
experiments were conducted on 30 male white rats of a
mixed population weighing 150-190 g. The experimental
ulcer model was induced by the method of V.A. Vertelkin
as modified by I.A. The animals were divided into 5 groups
of 6 individuals each: Intact group (control); animals
with experimental ulcers; ulcer without treatment; ul
cer + esomeprazole + amoxicillin + tetracycline; ulcer +
esomeprazole + amoxicillin + furazolidone. Results: Bio
chemical analysis showed that the furazolidone regimen
significantly increased the concentration of L-lactate and
malondialdehyde, indicating increased activity of anaer
obic glycolysis and increased lipid peroxidation. These
changes indicate worsening microcirculatory disorders
and increased oxidative stress in the gastric mucosa. The
combination of esomeprazole, amoxicillin and tetracy
cline resulted in a significant decrease in both MDA and
L-lactate levels, indicating a pronounced antioxidant ef fect and normalization of glycolytic metabolism. Conclu
sions: The obtained data confirm the therapeutic benefit
of triple therapy with tetracycline for the correction of
metabolic disorders in the gastric mucosa and improving
the results of peptic ulcer treatment.
