Abstract:
Diabetes mellitus (DM) is a chronic autoimmune disease. When purulent-necrotic lesions of diabetic heel syndrome appear, an inflammatory reaction appears and manifests itself in the form of a local reaction, which can lead to a systemic response. As a result of bacterial action, under the influence of humoral factors, activation occurs in the main phagocytosis cells – neutrophils (polymorphonuclear leukocytes), monocytes (macrophages) and platelets. Activated cells begin to produce inflammatory mediators (cytokines) into the blood, which are involved in the regulation of vascular tone, hemostasis, and cell proliferation.
