ROLE OF SYSTEMIC INFLAMMATORY BIOMARKERS IN DETERMINING DISEASE ACTIVITY AND CLINICAL PROGRESSION OF RHEUMATOID ARTHRITIS

dc.contributor.author	Shakhnoza Kh. Mirzayeva - independent researcher Aida A. Eshmurzaeva - D.M.Sc, professor Khamid M. Marufkhanov - D.M.Sc. Tashkent State Medical University, Tashkent, Uzbekistan sh.mirzayeva5358@gmail.com
dc.date.accessioned	2025-11-08T09:13:20Z
dc.date.available	2025-11-08T09:13:20Z
dc.date.issued	2025-04-10
dc.identifier.uri	http://repo.tma.uz/xmlui/handle/1/2331
dc.description.abstract	Growing evidence suggests that systemic inflammatory mediators play a decisive role in rheumatoid arthritis progression. Within this research, the levels and diagnostic value of key biomarkers were assessed among patients with different clinical forms of RA. The extra-articular variant displayed a more aggressive inflammatory profile, accompanied by significantly raised IL-1, IL-6, and TNF-α. Furthermore, increased TLR2 activity was identified as a critical factor in disease mechanisms.	en_US
dc.language.iso	other	en_US
dc.subject	Rheumatoid Arthritis (RA), Inflammatory Biomarkers, TLR2 (Toll-Like Receptor 2), Cytokines (IL-1, IL-6, TNF-α), Extra-Articular RA, Articular RA, Disease Activity Score (DAS28).	en_US
dc.title	ROLE OF SYSTEMIC INFLAMMATORY BIOMARKERS IN DETERMINING DISEASE ACTIVITY AND CLINICAL PROGRESSION OF RHEUMATOID ARTHRITIS	en_US
dc.type	Article	en_US