The Relationship Between The Expression Of LRP1, LDLR, And LOX1 Receptors With The Steatosis Index And Liver Stiffness In Patients With Non-Alcoholic Fatty Liver Disease

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition characterized by complex interactions between metabolic dysfunction, lipid accumulation, inflammation, and progressive fibrosis. Molecular mechanisms underlying these processes increasingly highlight the role of receptor genes involved in lipid transport and oxidative stress regulation. The present study aimed to investigate the association between the expression levels of LRP1, LDLR, and LOX1 receptor genes and key morphometric and non-invasive indicators of hepatic involvement in NAFLD. A cohort of patients with varying degrees of steatosis and fibrosis underwent molecular-genetic analysis, elastographic assessment of liver stiffness (Young’s modulus), and evaluation of the Fatty Liver Index (FLI). The results demonstrated that decreased expression of LRP1 and LDLR was significantly associated with higher FLI values, indicating a potential contribution of impaired receptor-mediated lipid uptake to the