PNPLA3 GENE POLYMORPHISM AS A GENETIC MARKER OF BONE MINERAL DENSITY DISORDERS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

Abstract

The results of investigation of bone mineral density of 100 patients with nonalcoholic fatty liver disease (NAFLD) were presented in the article. Studies included a definition of biochemical markers of bone metabolism and ultrasonic densitomety of bone density. Significantly increasing of bone resorption of of bcross laps indicator and reduction of densitometric parameters T and Z - criteria in patients with NAFLD and pathological G allele of PNPLA 3 (rs738409) were revealed.