Abstract:
The impaired regenerative capacity of post-extraction wounds in patients with type 1 diabetes mellitus continues to represent a major problem in outpatient oral surgery. Chronic hyperglycemia, microangiopathy, and immune dysfunction lead to delayed epithelialization, prolonged inflammation, and a higher risk of alveolitis. The purpose of this study was to evaluate the clinical effectiveness of autologous platelet-rich fibrin (PRF) in optimizing socket healing and reducing postoperative complications in diabetic patients. A randomized split-mouth clinical trial involving 48 individuals with type 1 diabetes mellitus was performed. PRF was placed into one extraction socket, while
the contralateral socket served as a control. Healing dynamics, pain level, incidence of alveolitis, and bone density were assessed for six weeks. Application of PRF significantly accelerated epithelial regeneration, reduced postoperative pain, lowered alveolitis occurrence more than fivefold, and improved bone density by 12.6% compared
with conventional management. These findings indicate that PRF is an effective, safe, and accessible regenerative material that enhances postoperative outcomes in diabetic patients.
