КОРРЕКЦИЯ КУРСА ХИМИОТЕРАПИИ В ПРОФИЛАКТИКЕ РЕЦИДИВА ЭХИНОКОККОЗА ПЕЧЕНИ

Abstract

To improve the quality of treatment of patients with liver echinococcosis by developing effective methods to reduce the number of relapses of the disease. Material and methods: 371 patients with liver echinococcosis were under observation. In order to assess the effect of albendazole in various dosages on the germinal forms of echinococcosis, morphological studies of the internal organs were carried out in 32 sheep infected with echinococcosis in natural conditions. Results: Chemotherapy with albendazole was started no later than one month after surgical treatment. In the comparison group, postoperative chemotherapy was performed in 112 (43.8%) patients according to the traditional scheme. During treatment, an increase in the average concentration of AST and ALT after the first course of chemotherapy was noted, up to 0.55±0.05 and 0.88±0.08 mmol/L, respectively. Conclusions: Experimental studies have shown that in areas remote from the primary echinococcal cyst there are microscopically identifiable germinal microcysts, which can lead to the development of a relapse of the disease after removal of large cysts.