METOBOLIK SINDROMDA XOLESTERIN METABOLIZMINING O‘ZGARISHI

Axmedova Surayyo Nurali qizi; Xoliqov Xo’jaaxror Baxodir o’g’li; Raxmatillayev Boburjon Baxodir og’li; Islomov Farhod Umar og’li

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dc.contributor.author	Axmedova Surayyo Nurali qizi
dc.contributor.author	Xoliqov Xo’jaaxror Baxodir o’g’li
dc.contributor.author	Raxmatillayev Boburjon Baxodir og’li
dc.contributor.author	Islomov Farhod Umar og’li
dc.date.accessioned	2025-12-24T18:17:20Z
dc.date.available	2025-12-24T18:17:20Z
dc.date.issued	2025-12-05
dc.identifier.issn	3060-4648
dc.identifier.uri	http://repo.tma.uz/xmlui/handle/1/2818
dc.description.abstract	Metabolik sindrom global epidemiologik yukning asosiy drayverlaridan biri bo‘lib, xolesterin almashinuvining molekulyar darajadagi buzilishlari ushbu sindrom patogenezining markazida turadi. Adabiyotlar sharhi so‘nggi 15 yil ichida e’lon qilingan klinik va eksperimental tadqiqotlarga tayanib, LDL(past zichlikdagi lipoprotein)-parchalanish jarayonlarining sekinlashuvi, HDL(yuqori zichlikdagi lipoprotein)-siklning disfunksiyasi, jigar sitoxrom P450 tizimi faolligining pasayishi, insulin-rezistent to‘qimalarda lipolizning deregulatsiyasi hamda aterogen dislipidemiya shakllanishini yoritadi. Turli mamlakatlarda olib borilgan kohort tadqiqotlar metabolik sindromli bemorlarda ateroskleroz xavfining 2,3–3,1 baravar yuqoriligini ko‘rsatadi (National Health and Nutrition Examination Survey, 2022; uropean Prospective Investigation into Cancer and Nutrition – Cardiovascular Disease, 2020). Ushbu maqola metabolik sindrom kontekstida xolesterin homeostazini belgilovchi fermentlar, retseptorlar va transport tizimlari dinamikasini ilmiy asosda tahlil qiladi	en_US
dc.publisher	EDUCATIONAL YIELD INSIGHTS & BREAKTHROUGHS	en_US
dc.subject	metabolik sindrom; xolesterin metabolizmi; aterogen dislipidemiya; LDL; HDL; insulin rezistentlik; sitoxrom P450; jigar steatozi; lipoproteinlar.	en_US
dc.title	METOBOLIK SINDROMDA XOLESTERIN METABOLIZMINING O‘ZGARISHI	en_US
dc.type	Article	en_US