RISK FACTORS FOR THE DEVELOPMENT AND FEATURES OF THE COURSE OF URATE NEPHROPATHY IN FREQUENTLY ILL CHILDREN

Abstract

Objective: To determine the prevalence, risk factors, and clinical features of urate nephropathy (UN) in frequently ill children (FIC). Materials and Methods: The study was conducted at the multidisciplinary clinic of Tashkent State Medical University, in the Department of Pediatric Nephrology, during the period from 2022 to 2024. At Stage I, a retrospective, in-depth analysis of the medical records of 1,323 children aged 3 to 12 years who received inpatient treatment was carried out. At Stage II, a comprehensive clinical examination was conducted on 120 children with a confirmed diagnosis of UN. Results: Among frequently ill children, diseases of the urinary system, including urate nephropathy, occur significantly more often than in healthy children. In FIC, UN is commonly associated with background diseases such as tonsillitis, bronchitis, gastroduodenitis, and others, and is characterized by marked seasonality. The main risk factors for the development of the disease include maternal comorbidities, which may increase the likelihood of kidney tissue pathologies in the child in the future. In children with UN, clinical manifestations show age-specific features depending on the developmental stage of the child. Conclusion: To prevent complications of urate nephropathy in frequently ill children, early detection of urate metabolism disorders and timely correction are essential.