Abstract:
Preeclampsia is a pathological condition that develops predominantly in the third trimester of pregnancy and
whose etiology has not yet been fully elucidated. It is characterized by arterial hypertension, proteinuria, and a range of other
clinical manifestations. In preeclampsia, an excessive stress-induced response of the adrenal glands is observed, leading to
increased morphofunctional activity and subsequent damage to cellular elements of all adrenal layers. As a result, the adrenal
cortex demonstrates pronounced vascular congestion accompanied by focal diapedetic hemorrhages, as well as dystrophic
and necrobiotic changes across all cortical zones. Notably, the zona fasciculata of the adrenal cortex is the most vulnerable
region; hyperfunctional activity of the glandular epithelium in this zone contributes to the development of massive hyperemia
and focal necrosis.
