Abstract:
To improve the quality of early diagnosis
of cardiovascular pathology in patients with silicosis by
studying the role of cytokines and hemodynamic disorders
in the development of fibrosis and endothelial dysfunction.
Material and methods: All 146 people included in the
study (126 in the main group and 20 healthy volunteers)
underwent echocardiography using an ultrasound ma
chine equipped with a sector transducer with a frequen
cy of 4.5-7 MHz. The examination was performed in the
morning, with the patient lying on his left side and on his
back. The day before and on the day of the study, partici
pants were advised to avoid intense physical activity and
heavy meals. Results: The conducted correlation anal
ysis revealed a relationship between the left ventricular
ejection fraction and a number of pathogenetic markers
of silicosis, including systemic inflammation indicators
(activity of myeloperoxidase, neutrophil elastase, TNF-α,
interleukin-8 concentrations) and markers of endothelial
dysfunction (endothelin-1 concentration). Conclusions:
Innovative approaches to treatment and prevention are
needed to prevent serious long-term cardiovascular com
plications in individuals at occupational risk.
